Recombinant ESAT-6-CFP10 Fusion Protein Induction of Th1/Th2 Cytokines and FoxP3 Expressing Treg Cells in Pulmonary TB.
Identifieur interne : 000567 ( Main/Exploration ); précédent : 000566; suivant : 000568Recombinant ESAT-6-CFP10 Fusion Protein Induction of Th1/Th2 Cytokines and FoxP3 Expressing Treg Cells in Pulmonary TB.
Auteurs : Dolly Jackson-Sillah [Ghana] ; Jacqueline M. Cliff ; Gloria Ivy Mensah ; Emmanuel Dickson ; Sandra Sowah ; John K A. Tetteh ; Kwasi K. Addo ; Tom H M. Ottenhoff ; Graham Bothamley ; Hazel M. DockrellSource :
- PloS one [ 1932-6203 ] ; 2013.
Abstract
Early secretory antigenic target 6 (ESAT-6) and culture filtrate protein 10 (CFP-10) are Mycobacterium tuberculosis (Mtb)-specific antigens that are secreted by actively metabolising bacteria and contribute to the virulence of the bacteria. Their ability to induce Treg and Th2 responses, particularly during the first two weeks of treatment, has not been comprehensively examined to date. The purpose of this work was to characterise Th1, Th2 and Treg responses to rESAT-6-CFP10 fusion protein in TB patients before and during the intensive phase of treatment and in healthy M.bovis BCG vaccinated donors.
DOI: 10.1371/journal.pone.0068121
PubMed: 23826366
Affiliations:
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Cliff</name></author><author><name sortKey="Mensah, Gloria Ivy" sort="Mensah, Gloria Ivy" uniqKey="Mensah G" first="Gloria Ivy" last="Mensah">Gloria Ivy Mensah</name></author><author><name sortKey="Dickson, Emmanuel" sort="Dickson, Emmanuel" uniqKey="Dickson E" first="Emmanuel" last="Dickson">Emmanuel Dickson</name></author><author><name sortKey="Sowah, Sandra" sort="Sowah, Sandra" uniqKey="Sowah S" first="Sandra" last="Sowah">Sandra Sowah</name></author><author><name sortKey="Tetteh, John K A" sort="Tetteh, John K A" uniqKey="Tetteh J" first="John K A" last="Tetteh">John K A. Tetteh</name></author><author><name sortKey="Addo, Kwasi K" sort="Addo, Kwasi K" uniqKey="Addo K" first="Kwasi K" last="Addo">Kwasi K. Addo</name></author><author><name sortKey="Ottenhoff, Tom H M" sort="Ottenhoff, Tom H M" uniqKey="Ottenhoff T" first="Tom H M" last="Ottenhoff">Tom H M. 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Their ability to induce Treg and Th2 responses, particularly during the first two weeks of treatment, has not been comprehensively examined to date. The purpose of this work was to characterise Th1, Th2 and Treg responses to rESAT-6-CFP10 fusion protein in TB patients before and during the intensive phase of treatment and in healthy M.bovis BCG vaccinated donors.</div></front></TEI><affiliations><list><country><li>Ghana</li></country><region><li>Région du Grand Accra</li></region><settlement><li>Accra</li></settlement></list><tree><noCountry><name sortKey="Addo, Kwasi K" sort="Addo, Kwasi K" uniqKey="Addo K" first="Kwasi K" last="Addo">Kwasi K. Addo</name><name sortKey="Bothamley, Graham" sort="Bothamley, Graham" uniqKey="Bothamley G" first="Graham" last="Bothamley">Graham Bothamley</name><name sortKey="Cliff, Jacqueline M" sort="Cliff, Jacqueline M" uniqKey="Cliff J" first="Jacqueline M" last="Cliff">Jacqueline M. 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